Down-regulation of Hsp90 could change cell cycle distribution and increase drug sensitivity of tumor cells
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چکیده
منابع مشابه
Down-regulation of HSP40 gene family following OCT4B1 suppression in human tumor cell lines
Objective(s): The OCT4B1, as one of OCT4 variants, is expressed in cancer cell lines and tissues more than other variants and plays an important role in apoptosis and stress (heat shock protein) pathways. The present study was designed to determine the effects of OCT4B1 silencing on expressional profile of HSP40 gene family expression in three different human tumor cell lines. Materials and Met...
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Cell cycle regulation and anticancer drug discovery
Cellular growth, development, and differentiation are tightly controlled by a conserved biological mechanism: the cell cycle. This cycle is primarily regulated by cyclin-dependent kinase (CDK)-cyclin complexes, checkpoint kinases, and CDK inhibitors. Deregulation of the cell cycle is a hallmark of the transformation of normal cells into tumor cells. Given its importance in tumorigenesis, severa...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 1999
ISSN: 1007-9327
DOI: 10.3748/wjg.v5.i3.199